Treatment with interferon of chronic hepatitis B associated with antibody to hepatitis B e antigen
โ Scribed by Brunetto, Maurizia Rossana; Oliveri, Filippo; Demartini, Alberto; Calvo, Pierluigi; Manzini, Paola; Cerenzia, Maria Torrani; Bonino, Ferruccio
- Book ID
- 121939832
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 255 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0168-8278
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A commercial radioimmunoassay was adapted to detect serum Dane particle-associated HBeAg in patients whose sera contained the homologous antibody. HBeAg was released from Dane particles with guanidine HC1. Dane particles were separated from anti-HBe by gel-filtration (Sepharose 4B) and ultracentrif
The course of chronic hepatitis B was studied in 30 patients who had antibody to hepatitis e antigen and hepatitis B virus DNA in the serum and hepatitis B core antigen in the liver. Over a 2-year period, no patient experienced a sustained spontaneous remission of disease, and follow-up liver histol