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Dane Particle-Associated Hepatitis B e Antigen in Patients with Chronic Hepatitis B Virus Infection and Hepatitis B e Antibody

✍ Scribed by Giovanni Raimondo; Serafino Recchia; Carla Lavarini; Osvaldo Crivelli; Mario Rizzetto

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
642 KB
Volume
2
Category
Article
ISSN
0270-9139

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✦ Synopsis

A commercial radioimmunoassay was adapted to detect serum Dane particle-associated HBeAg in patients whose sera contained the homologous antibody. HBeAg was released from Dane particles with guanidine HC1.

Dane particles were separated from anti-HBe by gel-filtration (Sepharose 4B) and ultracentrifugation of the eluate. Dane particle-HBeAg was tested in 45 HBsAg carriers with anti-HBe and was present in 8 (18%) carriers, all of whom had chronic liver disease. By contrast, HBeAg was not found in 10 carriers with normal liver histology. Serum or liver HBcAg was found in 6 of 8 patients with Dane particle-HBeAg. None of the carriers without Dane particle-HBeAg had other markers of hepatitis B virion synthesis.

We conclude that Dane particle-HBeAg provides a sensitive index of active hepatitis B virus replication, a guide to the presence of chronic hepatitis in HBsAg carriers with anti-HBe, and a noninvasive method to follow infection in these patients.

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