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Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients

✍ Scribed by Lung-Ji Chang; Jules Dienstag; Don Ganem; Harold Varmus

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
584 KB
Volume
10
Category
Article
ISSN
0270-9139

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✦ Synopsis

By the use of a truncated recombinant hepatitis B virus polymerase antigen, we have characterized a series of patient sera for anti-hepatiti.s B virus polymerase antibodies. Seven of 54 (13%) had antipolymerase antibodies detectable by Western blot analysis, and no close correlation was apparent between the disease status and patient's immune response against hepatitis B virus polymerase antigen. Our results indicate that serologic responses to the viral polymerase are demonstrable but suggest that such antibodies are not likely to be clinically useful as diagnostic or prognostic markers of infection.

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