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Treatment with all-trans retinoic acid in acute promyelocytic leukemia reduces early deaths in children

✍ Scribed by G. Mann; D. Reinhardt; J. Ritter; J. Hermann; K. Schmitt; H. Gadner; U. Creutzig

Publisher
Springer
Year
2001
Tongue
English
Weight
74 KB
Volume
80
Category
Article
ISSN
0939-5555

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## Abstract ## Background Due to severe side effects in virtually all children treated with a standard dose of 45 mg/m^2^/day all‐__trans__‐retinoic acid (ATRA) for acute promyelocytic leukemia (APL) the AML‐BFM study group reduced the dosage to 25 mg/m^2^/day. For the lack of data on the use of A

ALL-TRANS RETINOIC ACID (ATRA) IN THE TR
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Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,