𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Treatment results of bisphosphonate-related osteonecrosis of the jaws

✍ Scribed by Arno Wutzl; Edwin Biedermann; Felix Wanschitz; Rudolf Seemann; Clemens Klug; Arnulf Baumann; Franz Watzinger; Kurt Schicho; Rolf Ewers; Gabriele Millesi

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
238 KB
Volume
30
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Osteonecrosis of the jaws occurs after the administration of bisphosphonates. An unequivocal treatment strategy is yet to be devised. We assess the treatment of patients with bisphosphonate‐related osteonecrosis of the jaws (BRONJ).

Methods.

The investigators studied a prospective cohort of 58 patients 6 months after surgical treatment of BRONJ. Outcome variables were the status of the mucosa, the visual analog score of pain, and prosthetic rehabilitation. Preoperative staging results were compared with the postoperative outcome and statistically evaluated.

Results.

Of 58 patients, 41 surgically treated patients could be followed up after a mean period of 189 (±23) days. Twenty‐four (58.5%) were free of pain and had an intact mucosa. A statistically significant improvement was registered between preoperative and postoperative staging (p <.01); 11 of 12 patients who had been treated with a flap procedure for soft tissue closure had an intact mucosa.

Conclusions.

This is the first prospective study to report the outcome of treatment in a cohort of patients with BRONJ. Minimal resection of necrotic bone and local soft tissue closure might be a feasible treatment strategy in patients with established BRONJ. © 2008 Wiley Periodicals, Inc. Head Neck 2008

📜 SIMILAR VOLUMES

Treatment protocols of bisphosphonate-re
Treatment protocols of bisphosphonate-related osteonecrosis of the jaws
✍ Athanassios Kyrgidis; Georgios Koloutsos; Konstantinos Vahtsevanos 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 48 KB 👁 2 views

We read with great interest the article by Wutzl et al, 1 reporting a well-designed prospective study for the treatment of bisphosphonate-related osteonecrosis of the jaws (BRONJ) in a cohort of multiple myeloma, breast cancer, and other diseases in patients. The authors duly report patients' under

Factors influencing surgical treatment o
Factors influencing surgical treatment of bisphosphonate-related osteonecrosis of the jaws
✍ Arno Wutzl; Sebastian Pohl; Irene Sulzbacher; Rudolf Seemann; Günter Lauer; Rolf 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 480 KB 👁 2 views

## Abstract ## Background Bisphosphonates are known to be associated with osteonecrosis of the jaw. We assess factors underlying the success of surgical treatment in patients with bisphosphonate‐related osteonecrosis of the jaw (BRONJ). ## Methods Fifty‐eight patients were investigated 6 months

A preliminary report about treatment of
A preliminary report about treatment of bisphosphonate related osteonecrosis of the jaw with Er:YAG laser ablation
✍ Stefan Stübinger; Jan-Philipp Dissmann; Nicole Chambron Pinho; Belma Saldamli; O 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB 👁 1 views

## Abstract ## Background and Objectives This preliminary report describes a new laser‐assisted treatment option for the emerging complication of bisphosphonate related osteonecrosis (BON) of the jaw. ## Materials and Methods In eight tumour patients (three women, five men) ten bony lesions in t

Bisphosphonate-related osteonecrosis of
Bisphosphonate-related osteonecrosis of the skull base
✍ Aayesha M. Khan; Raj Sindwani 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB

## Abstract Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity. Most cases are managed by oral surgeons with only a handful of reports appearing in the otolaryngology literat

Incidence and risk factors of bisphospho
Incidence and risk factors of bisphosphonate-associated osteonecrosis of the jaws
✍ Matthew R. Stumpe; Rakesh K. Chandra; Furhan Yunus; Sandeep Samant 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB 👁 2 views

## Abstract ## Background Intravenous bisphosphonate therapy has been used for treatment of benign and malignant bone diseases and has been linked to osteonecrosis of the jaws. ## Methods Records of 638 patients treated with intravenous bisphosphonates were reviewed. Drug used, number of infusio

Bisphosphonate-associated osteonecrosis
Bisphosphonate-associated osteonecrosis of the jaws: The limits of a conservative approach
✍ Giancarlo Tirelli; Matteo Biasotto; Silvia Chiandussi; Franca Dore; Elena De Nar 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB 👁 1 views

## Abstract ## Background. An increasing number of cases of osteonecrosis of the jaws (ONJ) in patients treated with bisphosphonates has been reported in the literature. ONJ significantly affects the patients' quality of life and its management is still extremely difficult. ## Methods. A woman w