✦ LIBER ✦

Bisphosphonate-associated osteonecrosis of the jaws: The limits of a conservative approach

✍ Scribed by Giancarlo Tirelli; Matteo Biasotto; Silvia Chiandussi; Franca Dore; Elena De Nardi; Roberto Di Lenarda

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 175 KB
Volume: 31
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21019

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

An increasing number of cases of osteonecrosis of the jaws (ONJ) in patients treated with bisphosphonates has been reported in the literature. ONJ significantly affects the patients' quality of life and its management is still extremely difficult.

Methods.

A woman with ONJ secondary to therapy with zoledronic acid came to our attention for recurrent oral infections and orocutaneous fistula unresponsive to antibiotic therapy combined with minor surgical debridements. The patient underwent major surgery to remove the fistula and clean the necrotic bone and soft tissues; a lobed skin platysma flap was used to close the defect. The treatment outcome was good.

Conclusion.

When ONJ fails to respond to antibiotic therapy and surgical debridements, a more invasive surgical approach may be necessary to guarantee a better quality of life for the patient. © 2009 Wiley Periodicals, Inc. Head Neck, 2009

📜 SIMILAR VOLUMES

Incidence and risk factors of bisphospho

Incidence and risk factors of bisphosphonate-associated osteonecrosis of the jaws

✍ Matthew R. Stumpe; Rakesh K. Chandra; Furhan Yunus; Sandeep Samant 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB 👁 2 views

## Abstract ## Background Intravenous bisphosphonate therapy has been used for treatment of benign and malignant bone diseases and has been linked to osteonecrosis of the jaws. ## Methods Records of 638 patients treated with intravenous bisphosphonates were reviewed. Drug used, number of infusio

Incidence of bisphosphonate-associated o

Incidence of bisphosphonate-associated osteonecrosis of the jaws in breast cancer patients

✍ Christian Walter; Bilal Al-Nawas; Andreas du Bois; Laura Buch; Philipp Harter; K 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

Treatment results of bisphosphonate-rela

Treatment results of bisphosphonate-related osteonecrosis of the jaws

✍ Arno Wutzl; Edwin Biedermann; Felix Wanschitz; Rudolf Seemann; Clemens Klug; Arn 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 238 KB 👁 2 views

## Abstract ## Background. Osteonecrosis of the jaws occurs after the administration of bisphosphonates. An unequivocal treatment strategy is yet to be devised. We assess the treatment of patients with bisphosphonate‐related osteonecrosis of the jaws (BRONJ). ## Methods. The investigators studie

Treatment protocols of bisphosphonate-re

Treatment protocols of bisphosphonate-related osteonecrosis of the jaws

✍ Athanassios Kyrgidis; Georgios Koloutsos; Konstantinos Vahtsevanos 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 48 KB 👁 2 views

We read with great interest the article by Wutzl et al, 1 reporting a well-designed prospective study for the treatment of bisphosphonate-related osteonecrosis of the jaws (BRONJ) in a cohort of multiple myeloma, breast cancer, and other diseases in patients. The authors duly report patients' under

Patients with bisphosphonates-associated

Patients with bisphosphonates-associated osteonecrosis of the jaw have reduced circulating endothelial cells

✍ A Allegra; G Oteri; E Nastro; A Alonci; G Bellomo; V Del Fabro; E Quartarone; C 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB 👁 1 views

## Abstract Osteonecrosis of the jaws (ONJ) associated with the use of bisphosphonates is a newly described entity. To elucidate the mechanism leading to ONJ and to test the hypothesis that in patients with ONJ the bisphosphonates may interfere with endothelial cell proliferation, using flow cytome

Factors influencing surgical treatment o

Factors influencing surgical treatment of bisphosphonate-related osteonecrosis of the jaws

✍ Arno Wutzl; Sebastian Pohl; Irene Sulzbacher; Rudolf Seemann; Günter Lauer; Rolf 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 480 KB 👁 2 views

## Abstract ## Background Bisphosphonates are known to be associated with osteonecrosis of the jaw. We assess factors underlying the success of surgical treatment in patients with bisphosphonate‐related osteonecrosis of the jaw (BRONJ). ## Methods Fifty‐eight patients were investigated 6 months