Treatment of two patients with acquired factor VIII inhibitors using cyclophosphamide and prednisone
β Scribed by Mark S. Hertzberg; Emmanuel Favaloro; Jerry Koutts
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 250 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0361-8609
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The treatment of Factor VIII inhibitors remains controversial and no standard therapy exists. We describe in this report two consecutive patients with this inhibitor that responded to cyclosporin. Clinical improvement of the bleeding diathesis, a return to normal of the PTT, a decrease in the level
A rare cause of a spontaneous, life threatening coagulopathy in adults is the development of autoantibodies to factor VIII. We recently had the opportunity to treat seven patients with this disorder. After stabilization, they were given a regimen consisting of prednisone and oral cyclophosphamide. A