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Acquired factor VIII inhibitors?successful treatment with an oral outpatient regimen

✍ Scribed by Bayer, Ruthee-Lu; Lichtman, Stuart M.; Allen, Steven L.; Budman, Daniel R.; Buchbinder, Aby; Fetten, James; Kolitz, Jonathan; Loscalzo, John

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 14 KB
Volume: 60
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199901)60:1<70::aid-ajh12>3.0.co;2-d

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✦ Synopsis

A rare cause of a spontaneous, life threatening coagulopathy in adults is the development of autoantibodies to factor VIII. We recently had the opportunity to treat seven patients with this disorder. After stabilization, they were given a regimen consisting of prednisone and oral cyclophosphamide. All patients had a complete response to treatment. The median time to response was three weeks. Durable remissions were achieved, making this oral regimen an acceptable treatment for this disorder. Am.

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