A rare cause of a spontaneous, life threatening coagulopathy in adults is the development of autoantibodies to factor VIII. We recently had the opportunity to treat seven patients with this disorder. After stabilization, they were given a regimen consisting of prednisone and oral cyclophosphamide. A
Successful treatment of acquired factor VIII inhibitors with cyclosporin
β Scribed by Brox, Alan G.; Laryea, Horace; Pelletier, Marc
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 11 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0361-8609
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β¦ Synopsis
The treatment of Factor VIII inhibitors remains controversial and no standard therapy exists. We describe in this report two consecutive patients with this inhibitor that responded to cyclosporin. Clinical improvement of the bleeding diathesis, a return to normal of the PTT, a decrease in the level of the inhibitor, and a return to normal of the factor VIII level followed use of this drug. We believe that cyclosporin is effective in the treatment of factor VIII inhibitors and deserves further investigation.
π SIMILAR VOLUMES
Postpartum factor VIII inhibitors are rare; thus, collecting clinical and treatment data may provide valuable information in guiding patient management. This paper reports the results of a survey of United States and Canadian hemophilia centers on 14 patients with postpartum acquired factor VIII inh