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Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: Results of a twenty-four–week, multicenter, randomized, double-blind, placebo-controlled trial

✍ Scribed by Stanley Cohen; Eric Hurd; John Cush; Michael Schiff; Michael E. Weinblatt; Larry W. Moreland; Joel Kremer; Moraye B. Bear; William J. Rich; Dorothy McCabe


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
149 KB
Volume
46
Category
Article
ISSN
0004-3591

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✍ Norihiro Nishimoto; Kazuyuki Yoshizaki; Nobuyuki Miyasaka; Kazuhiko Yamamoto; Sh 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB 👁 2 views

## Abstract ## Objective Interleukin‐6 (IL‐6) is a pleiotropic cytokine that regulates the immune response, inflammation, and hematopoiesis. Overproduction of IL‐6 plays pathologic roles in rheumatoid arthritis (RA), and the blockade of IL‐6 may be therapeutically effective for the disease. This s