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Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: A large, international, multicenter, placebo-controlled trial

โœ Scribed by Roy M. Fleischmann; Joy Schechtman; Ralph Bennett; Malcolm L. Handel; Gerd-Rudiger Burmester; John Tesser; Dennis Modafferi; Jennifer Poulakos; Gordon Sun


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
80 KB
Volume
48
Category
Article
ISSN
0004-3591

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## Abstract ## Objective To investigate the effects of tocilizumab (TCZ) added to a stable dosage of methotrexate (MTX) on biochemical markers of bone and cartilage metabolism in patients in the multicenter doubleโ€blind, placeboโ€controlled OPTION (Tocilizumab Pivotal Trial in Methotrexate Inadequa