Trapa bispinosa Starch as a Tablet Disintegrant

✍ Scribed by A. S. Bal; S. B. Joshi

• Book ID: 102408844
• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 231 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600630342

✦ Synopsis

steroids (18) and that of antibacterial agents, fusidic acid, cephalosporin PI, helvolic acid, and related compounds (19,20) have been reported. Cardiac glycosidesl (21-24) and steroidal glycosides isolated from starfish (25) also possess antiviral activity. Furthermore, the triterpenoid saponins (X-XIV, XVI, XIX, and XX) found to inhibit influenza virus in the present study were reported to be antibacterial agents (10).

At least one site of action of gymnemic acid A against influenza virus is indicated to be associated with relatively early events in the virus infectious cycle which may involve inhibition of virus-host cell attachment (1). Cardiac glycosides are believed to exhibit antiviral action by competing with infectious viruses for the virus-specific receptor sites on the cell membrane and adenosine triphosphatase molecules involved in virus-host cell interactions (24). The recent observation that gymnemic acid also inhibits adenosine triphosphatase activity (26) suggests that the mechanism of antiviral action of gymnemic acid may be similar to that proposed for cardiac glycosides.