Transporters as Drug Carriers: Structure, Function, Substrates (Methods and Principles in Medicinal Chemistry)

✍ Scribed by Gerhard Ecker, Peter Chiba, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

Year: 2009
Tongue: English
Leaves: 451
Series: Methods and Principles in Medicinal Chemistry 44
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

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