Transporters as Drug Carriers: Structure, Function, Substrates, Volume 44

✍ Scribed by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers(eds.)

• Year: 2009
• Tongue: English
• Leaves: 436
• Series: Methods and Principles in Medicinal Chemistry
• Category: Library

✦ Synopsis

This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.
As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general.
For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

✦ Table of Contents

Content:
Chapter 1 The ABC Transporters: Structural Insights into Drug Transport (pages 1–48): Robert C. Ford, Alhaji B. Kamis, Ian D. Kerr and Richard Callaghan
Chapter 2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters (pages 49–80): Marcal Pastor?Anglada, Miriam Molina?Arcas, Pedro Cano?Soldado and Francisco Javier Casado
Chapter 3 Organic Anion Transporting Polypeptides (Oatps/OATPs) (pages 81–112): Mine Yarim and Meric Koksal
Chapter 4 CNS ? Transporters as Drug Targets (pages 113–117): Klaus Gundertofte
Chapter 5 Bacterial Multidrug Transporters: Molecular and Clinical Aspects (pages 119–157): Olga Lomovskaya, Helen I. Zgurskaya and Keith Bostian
Chapter 6 Membrane Transporters in Pleiotropic Drug Resistance and Stress Response in Yeast and Fungal Pathogens (pages 159–193): Tobias Schwarzmuller, Cornelia Klein, Martin Valachovic, Walter Glaser and Karl Kuchler
Chapter 7 QSAR Studies on ABC Transporter – How to Deal with Polyspecificity (pages 195–214): Prof. Dr. Gerhard F. Ecker
Chapter 8 Drug Transporter Pharmacophores (pages 215–227): Sean Ekins
Chapter 9 Biological Membranes and Drug Transport (pages 229–262): Gert Fricker
Chapter 10 Transport at the Blood–Brain Barrier (pages 263–298): Winfried Neuhaus and Christian R. Noe
Chapter 11 Bile Canalicular Transporters (pages 299–324): Dirk R. de Waart and Ronald P. J. Oude Elferink
Chapter 12 Interplay of Drug Metabolizing Enzymes and ABC Transporter (pages 325–347): Walter Jager
Chapter 13 ABC Transporters – From Targets to Antitargets? (pages 349–362): Prof. Dr. Gerhard F. Ecker and Prof. Dr. Peter Chiba
Chapter 14 A Systems Biology View of Drug Transporters (pages 363–385): Sean Ekins and Dana L. Abramovitz
Chapter 15 Drug Transporters in Health and Disease (pages 387–415): Barbara Bennani?Baiti and Christian R. Noe