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Transmission of human non-a, non-b hepatitis to chimpanzees following failure to transmit gb agent hepatitis

✍ Scribed by Edward Tabor; Milton April; Robert J. Gerety; David A. Peterson; Leonard B. Seeff

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 384 KB
Volume: 5
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890050202

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Two colony‐born infant chimpanzees were inoculated with documented infectious serum containing the GB agent. Serum aminotransferase levels remained within normal limits in weekly serum samples, and no abnormalities were detected in weekly liver biopsy specimens. Each of these chimpanzees was subsequently inoculated with serum containing an agent of human non‐A, non‐B hepatitis. Each developed non‐A, non‐B hepatitis characterized by elevation of serum aminotransferase levels and histopathologic changes in liver biopsy specimens. Thus, the chimpanzee appears not to be susceptible to the GB agent, and prior inoculation with this agent does not appear to confer immunity to subsequent infection with human non‐A, non‐B hepatitis.

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