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Studies on transmission of human non-A, non-B hepatitis to marmosets

✍ Scribed by Toshiaki Watanabe; Jiro Katagiri; Hideo Kojirna; Tomoteru Kamimura; Fumihiro Ichida; Masahiko Ashida; Chuya Harnada; Takao Shibayama

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 1008 KB
Volume: 22
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890220205

No coin nor oath required. For personal study only.

✦ Synopsis

Two sera obtained from four healthy blood donors, which caused non-A, non-B post-transfusion hepatitis in two recipients, were experimentally inoculated into nine marmosets. Three of seven marmosets developed acute hepatitis characterized by the elevation of serum concentrations of glutamic pyruvic transaminase (GPT) and/or isocitric dehydrogenase (ICD) 8-11 weeks after inoculation. Four of seven showed histopathological changes of acute hepatitis in liver biopsy specimens during the biochemically acute phase. In electron microscopic examination, attached membrane-like structures, which consisted of two-unit membranes of two neighboring endoplasmic reticula with electron-dense material between them, were noted in cytoplasm of hepatocytes during the acute phase of hepatitis. Furthermore, acute-phase sera obtained from two animals were inoculated into four additional marmosets, and non-A, non-B hepatitis was successfully passaged in two of them. The results of this study indicate that certain species of marmoset monkeys are susceptible to human non-A, non-B hepatitis agents and provide a useful animal model for non-A, non-B hepatitis.

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