Further studies by immunofluorescence of the monoclonal antibodies associated with experimental non-A, non-B hepatitis in chimpanzees and their relation to D hepatitis
✍ Scribed by Yohko K. Shimizu; Robert H. Purcell; John L. Gerin; Stephen M. Feinstone; Yasushi Ono; Toshio Shikata
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 519 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
To further investigate the specificity of the monoclonal antibodies (48-1 and S-1) associated with non-A, non-B hepatitis, extensive immunofluoreecence studies were performed on liver biopsy specimens from chimpanzees with experimental hepatitis A, B, non-A, non-B or 6, or from normal chimpanzees. Both 48-1 and S-1 antibodies reacted in the same manner with liver biopsy specimens from 47 of 50 (94%) chimpanzees with acute or chronic non-A, non-B hepatitis and 15 of 18 (83%) chimpanzees with type D hepatitis.
Examinations of serial liver biopsy specimens revealed that the duration of expression of the antigen reacting with the antibodies in hepatocytes of chimpanzees infected with non-A, non-B viruses appeared to be longer than that of chimpanzees infected with the hepatitis b-virus.
By thin-section electron microscopy, the presence of the microtubular aggregates, identical to those previ-