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Translational research using the sodium/iodide symporter in imaging and therapy

✍ Scribed by June-Key Chung; JooHyun Kang


Book ID
105962170
Publisher
Springer
Year
2004
Tongue
English
Weight
167 KB
Volume
31
Category
Article
ISSN
0340-6997

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## Abstract ## Background. Gene therapy that uses delivery of the sodium‐iodide symporter (NIS) gene followed by radioiodide administration has been proposed as a novel form of radiotherapy for nonthyroidal cancers. ## Methods. In vitro [^125^I] iodide accumulation and efflux from cells was dete

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## Abstract The sodium iodide symporter (NIS) mediates iodide uptake into the thyroid. Because of this mechanism, differentiated thyroid cancer is susceptible for radioiodine therapy. Functional NIS expression in extrathyroidal tumors has been reported mainly in breast cancer. We screened colorecta