There has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non-invasively th
Translational research using the sodium/iodide symporter in imaging and therapy
β Scribed by June-Key Chung; JooHyun Kang
- Book ID
- 105962170
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 167 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0340-6997
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## Abstract ## Background. Gene therapy that uses delivery of the sodiumβiodide symporter (NIS) gene followed by radioiodide administration has been proposed as a novel form of radiotherapy for nonthyroidal cancers. ## Methods. In vitro [^125^I] iodide accumulation and efflux from cells was dete
## Abstract The sodium iodide symporter (NIS) mediates iodide uptake into the thyroid. Because of this mechanism, differentiated thyroid cancer is susceptible for radioiodine therapy. Functional NIS expression in extrathyroidal tumors has been reported mainly in breast cancer. We screened colorecta