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Genetically targeted radiotherapy of head and neck squamous cell carcinoma using the sodium-iodide symporter (NIS)

✍ Scribed by Andrew W. Gaut; Gang Niu; Kimberly J. Krager; Michael M. Graham; Douglas K. Trask; Frederick E. Domann

Book ID
102847104
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
579 KB
Volume
26
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

Gene therapy that uses delivery of the sodium‐iodide symporter (NIS) gene followed by radioiodide administration has been proposed as a novel form of radiotherapy for nonthyroidal cancers.

Methods.

In vitro [^125^I] iodide accumulation and efflux from cells was determined after treatment with an NIS‐expressing adenovirus (Ad‐NIS). A clonogenic survival assay and tumor growth experiment that used athymic mice were used to demonstrate the in vitro and in vivo cytotoxicity of Ad‐NIS treatment and [^131^I] iodide delivery.

Results.

Head and neck squamous cell carcinoma (HNSCC) cell lines treated with Ad‐NIS exhibit significant amounts of radioiodide accumulation and retention. In vitro HNSCC cell survival was significantly diminished after NIS gene delivery followed by administration of [^131^I] iodide. Moreover, NIS gene transfer/[^131^I] iodide administration dramatically attenuated HNSCC tumor formation in athymic mice.

Conclusions.

Our data demonstrate the feasibility of genetically targeted radiotherapy by use of the NIS gene as a possible therapeutic intervention in head and neck cancer. Β© 2004 Wiley Periodicals, Inc. Head Neck 26: 265–271, 2004

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