Transition-state analogues as inhibitors for GABA-aminotransferase
โ Scribed by MN Iskander; PR Andrews; DA Winkler; RI Brinkworth; C Di Paola; S Cavell; J Issa
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 716 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0223-5234
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๐ SIMILAR VOLUMES
A 200- to 1000-fold higher affinity for sialyltransferase is shown by compounds 1 and 2 relative to the natural substrate. These inhibitors, which are derived from the transition state of S 1-type sialyltransfer, contain a flat ring that is attached through a carbon atom with a phosphonate and a cyt
AbstractรSyntheses of the `Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxyยฏuoro-and 2-deoxy-analogues and others having modiยฎed bases.