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Transient myeloproliferative disorder with 11q23 aberration in two neonates with Down syndrome

✍ Scribed by B. Granzen; B. Bernhard; I. Reinisch; H. Skopnik; R. Mertens


Book ID
105990372
Publisher
Springer
Year
1998
Tongue
English
Weight
167 KB
Volume
77
Category
Article
ISSN
0939-5555

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## Abstract An infant with Down syndrome (DS) and RH isoimmunization developed transient myeloproliferative disorder (TMD) during the neonatal period. At 16 months she presented with acute nonlymphocytic leukemia (ANLL). Cytogenetic studies during TMD showed trisomy 21 only but new abnormalities em

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Transient myeloproliferative disorder (TMD) in neonates with Down syndrome is characterized by increased megakaryoblastic cells in the peripheral blood. Despite their spontaneous regression in weeks, prognosis is not always favorable because of fatal hepatic fibrosis. In this study, blood thrombopoi