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Mutation of the AML1/RUNX1 gene in a transient myeloproliferative disorder patient with Down syndrome

✍ Scribed by Taketani, T; Taki, T; Takita, J; Ono, R; Horikoshi, Y; Kaneko, Y; Sako, M; Hanada, R; Hongo, T; Hayashi, Y


Book ID
110055171
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
89 KB
Volume
16
Category
Article
ISSN
0887-6924

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## Abstract An infant with Down syndrome (DS) and RH isoimmunization developed transient myeloproliferative disorder (TMD) during the neonatal period. At 16 months she presented with acute nonlymphocytic leukemia (ANLL). Cytogenetic studies during TMD showed trisomy 21 only but new abnormalities em