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Distinct clones are associated with the development of transient myeloproliferative disorder and acute megakaryocytic leukemia in a patient with down syndrome

โœ Scribed by Hirokazu Kanegane; Sayaka Watanabe; Keiko Nomura; Gang Xu; Etsuro Ito; Toshio Miyawaki


Publisher
Carden Jennings Publishing
Year
2007
Tongue
English
Weight
299 KB
Volume
86
Category
Article
ISSN
0925-5710

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## Abstract An infant with Down syndrome (DS) and RH isoimmunization developed transient myeloproliferative disorder (TMD) during the neonatal period. At 16 months she presented with acute nonlymphocytic leukemia (ANLL). Cytogenetic studies during TMD showed trisomy 21 only but new abnormalities em

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