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Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations

✍ Scribed by Niimi, H; Harada, H; Harada, Y; Ding, Y; Imagawa, J; Inaba, T; Kyo, T; Kimura, A

Book ID: 110056657
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 287 KB
Volume: 20
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2404136

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## Abstract ## BACKGROUND It has been reported that point mutations of the ras gene occur frequently in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). However, the prognostic significance of ras gene mutations in patients with these disorders has been a controversial issue. Altho