Transient diabetes mellitus secondary to L-asparaginase therapy in acute leukemia
β Scribed by Paul C. Gillette; L. Leighton Hill; Kenneth A. Starling; Donald J. Fernbach
- Book ID
- 118537080
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- English
- Weight
- 202 KB
- Volume
- 81
- Category
- Article
- ISSN
- 1097-6833
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Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably
## Abstract Four patients with acute lymphocytic leukemia previously treated with conventional chemotherapy received intramuscular Lβasparaginase in combination with other chemotherapy for reinduction and maintenance therapy. These patients received the Lβasparaginase for 8, 14, 27, and 34+ months