๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

L-asparaginase reinduction and maintenance therapy in previously treated acute lymphocytic leukemia

โœ Scribed by Sieger, Lance ;Higgins, Gussie ;Ortega, Jorge ;Shore, Nomie ;Williams, Kenneth

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
371 KB
Volume
2
Category
Article
ISSN
0098-1532

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

Four patients with acute lymphocytic leukemia previously treated with conventional chemotherapy received intramuscular Lโ€asparaginase in combination with other chemotherapy for reinduction and maintenance therapy. These patients received the Lโ€asparaginase for 8, 14, 27, and 34+ months without demonstrating any significant adverse effects. Only 1 of the 4 was clearly resistant to the other chemotherapy, and 3 of 4 had recurrence of their disease while receiving Lโ€asparaginase. Lโ€asparaginase can be added to reinduction and maintenance regimens of patients resistant to other chemotherapy and is well tolerated for long periods when given intramuscularly weekly with other immunosuppressant agents.

๐Ÿ“œ SIMILAR VOLUMES

L-asparaginase-induced coagulopathy duri
L-asparaginase-induced coagulopathy during therapy of acute lymphocytic leukemia
โœ Sills, Richard H. ;Nelson, Douglas A. ;Stockman, James A. ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 132 KB

## Abstract Lโ€Asparaginaseโ€induced coagulation abnormalities were observed in all patients receiving this drug. All patients studied demonstrated low factor IX and fibrinogen levels and most (75%) had low levels of factor XI. Disturbances in other factors were much less frequent. Despite the presen

Cyclophosphamide-asparaginase-vincristin
Cyclophosphamide-asparaginase-vincristine-prednisone induction therapy in childhood acute lymphocytic and nonlymphocytic leukemia
โœ Diane M. Komp; Stephen L. George; John Falletta; Vita J. Land; Kenneth A. Starli ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 380 KB ๐Ÿ‘ 2 views

A remission-induction regimen for childhood leukemia using cyclophosphamide, asparaginase, vincristine, and prednisone (CAVP) was compared to standard vincristine-prednisone (VP) induction. The more intensive regimen was associated with a lower complete remission rate (81% vs 93%) and a higher early

Evaluation of cyclocytidine in reinducti
Evaluation of cyclocytidine in reinduction and maintenance therapy of children with acute nonlymphocytic leukemia previously treated with cytosine arabinoside: A report from children's cancer study group
โœ Movassaghi, Nasser ;Higgins, Gussie ;Pyesmany, Allan ;Baehner, Robert ;Chard, Ro ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 438 KB

A study of children in relapse with acute nonlymphocytic leukemia (ANLL) previously maintained in remission with combination chemotherapy including cytosine arabinoside (Ara-C) was undertaken by Children's Cancer Study Group (CCSG) to assess the efficacy of cyclocytidine (Cyclo-C), a depot Ara-C, co