✦ LIBER ✦

L-asparaginase-induced coagulopathy during therapy of acute lymphocytic leukemia

✍ Scribed by Sills, Richard H. ;Nelson, Douglas A. ;Stockman, James A.

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 132 KB
Volume: 4
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950040406

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

L‐Asparaginase‐induced coagulation abnormalities were observed in all patients receiving this drug. All patients studied demonstrated low factor IX and fibrinogen levels and most (75%) had low levels of factor XI. Disturbances in other factors were much less frequent. Despite the presence of markedly abnormal coagulation studies, clinical bleeding was not observed.

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