## Abstract Eleven patients with acute lymphocytic leukemia in relapse were treated with L‐asparaginase and cytosine arabinoside (1‐β‐D‐arabinofuranosylcytosine) in induction therapy and the same drugs plus cyclophosphamide in maintenance therapy. Three patients had complete remissions lasting 6, 1
Use of L-asparaginase and cytosine arabinoside for refractory acute lymphocytic leukemia with particular reference to T-cell leukemia
✍ Scribed by Steuber, C. Philip ;Levy, Gary J. ;Nix, William L. ;Shepherd, Dell A. ;Starling, Kenneth A. ;Fernbach, Donald J.
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 353 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Abstract
Ten patients with late‐stage acute lymphocytic leukemia were treated with L‐asparaginase and cytosine arabinoside. Complete remission was achieved in 8 patients including 5 of 5 patients with T‐cell leukemia. Major toxicity included anaphylactic reactions in 3 of the 10 patients.
📜 SIMILAR VOLUMES
Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete