๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Intracranial bleeding during therapy with L-asparaginase in childhood acute lymphocytic leukemia

โœ Scribed by Ch. Urban; W. -D. Sager

Book ID
104776374
Publisher
Springer
Year
1981
Tongue
English
Weight
674 KB
Volume
137
Category
Article
ISSN
0340-6997

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โœฆ Synopsis

Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably were related to the effect of L-asparaginase which was part of the treatment protocol. Central nervous system leukemia, intrathecal chemotherapy, cranial irradiation, extreme leukocytosis, or thrombopenia at the time of diagnosis or day of stroke did not appear to be predisposing factors in these cases.

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