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Transgenic mice expressing human glucocerebrosidase variants: Utility for the study of Gaucher disease

โœ Scribed by Sanders, Angela; Hemmelgarn, Harmony; Melrose, Heather L.; Hein, Leanne; Fuller, Maria; Clarke, Lorne A.


Book ID
122991691
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
915 KB
Volume
51
Category
Article
ISSN
1079-9796

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โœ L. Tomei; C. B. Eap; P. Baumann; L. Dente ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Springer ๐ŸŒ English โš– 259 KB

Sera from transgenic mice (TM) carrying human genes of alpha 1-acid glycoprotein (orosomucoid or ORM) have been analyzed by isoelectrofocusing and subsequent immunoblotting with antihuman ORM antibodies. With this technique it is possible to reveal selectively the human protein secreted in the TM se