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Expression and secretion of human glucocerebrosidase mediated by recombinant lentivirus vectors in vitro and in vivo: implications for gene therapy of Gaucher disease

✍ Scribed by Eun Young Kim; Young Bin Hong; Zhennan Lai; Hyon J Kim; Youl-Hee Cho; Roscoe O Brady; Sung-Chul Jung

Book ID: 116288342
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 396 KB
Volume: 318
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2004.04.040

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## Abstract While traditional metabolic engineering generally relies on the augmentation of specific genes and pathways in order to increase the yield of target proteins, the advent of RNA interference (RNAi) as a biological tool has given metabolic engineers another tool capable of rationally alte