𝔖 Bobbio Scriptorium
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Transgenic mice as immune system models

✍ Scribed by Grant Morahan

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
751 KB
Volume
3
Category
Article
ISSN
0952-7915

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✦ Synopsis

In the past year, transgenic mice have continued to be powerful models for the investigation of various features of the immune system, particularly for studies of lymphocyte differentiation and tolerance. Major achievements have included the definition of intra-thymic selection events in T-cell differentiation, and the demonstration of extra-thymic tolerance resulting from clonal energy.

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C.B-17 scid/scid mice are born with severe combined immunodeficiency. This defect in the maturation of T and B cells has provided a novel experimental system in which to study normal lymphoid differentiation and function in mouse and man.