Analysis of the immune system with transgenic mice: B cell development and lymphokines
โ Scribed by A. Iglesias
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 868 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1420-682X
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Mice simultaneously expressing the nude and xid mutations have a severe deficit of both mature T and B cells. We now report studies designed to determine at which point in B cell differentiation development is arrested. Nude-xid mice have normal numbers of hematopoietic colony forming units (CFU-s)
## Abstract Evidence is presented for the existence of immune T lymphocytes which have protective activity __in vivo__ against the lethal effects of a metastasizing tumor. ESb, the metastasizing tumor cell line of our model system, which is highly malignant in syngeneic DBA/2 mice, can be rejected