Transgenes in autoimmunity
โ Scribed by Myung-Shik Lee; Nora Sarvetnick
- Book ID
- 103972872
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 739 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
โฆ Synopsis
The ability of transgenic mice to express a specific protein in a specific tissue has enabled the mechanisms of self-tolerance and autoimmunity to be elucidated. Further studies, combined with more sophisticated methods of gene targeting, will provide insights into the pathway leading from loss of self-tolerance to autoimmunity.
๐ SIMILAR VOLUMES
Transgenic and knockout mice have been valuable tools for clarifying the roles of individual cell types and effector molecules in the pathogenesis of autoimmunity. During the past year, new strains have been added to the large array of transgenic mice, with broad or tissue-specific expression of tra