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Experimental autoimmune uveitis in HLA-B27 transgenic mice

✍ Scribed by G.A. Willbanks; D.S. Rootman; V. Jay; B. Wiggert; J. Chamberlain; R.D. Inman

Book ID
117415622
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
756 KB
Volume
53
Category
Article
ISSN
0198-8859

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Cell surface expression of human class I molecules in transgenic mice is dependent upon the available pool of [32-microglobulin ([32m) and the affinity between mouse ~2m and human class I molecules. HLA-B27 and HLA-Cw3 transgenes can be expressed in mouse strains of the H-2 haplotypes b,f, k, and s