Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)
β Scribed by Roussel, Martine F.; Dull, Thomas J.; Rettenmier, Carl W.; Ralph, Peter; Ullrich, Axel; Sherr, Charles J.
- Book ID
- 109748333
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 591 KB
- Volume
- 325
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/325549a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The product of the c --proto-oncogene is related to, and possibly identical with, the receptor for the macrophage colony-stimulating factor, M-CSF (CSF-1). Unlike the product of the v-erbB oncogene, which is a truncated version of the EGF receptor, the glycoprotein encoded by the v-@ oncogene retain
Colony stimulating factor-1 (CSF-1) is the primary regulator of the mononuclear phagocytic lineage acting through its transmembrane tyrosine kinase receptor, CSF-1R, that is the product of the c-fms proto-oncogene. Null mutations in either the ligand or the receptor genes result in a severe osteopet