Inhibition of the c-fms proto-oncogene autocrine loop and tumor phenotype in glucocorticoid stimulated human breast carcinoma cells

Hormonal regulation of the c-fms proto-o

Hormonal regulation of the c-fms proto-oncogene in breast cancer cells is mediated by a composite glucocorticoid response element

✍ Maryann B. Flick; Eva Sapi; Barry M. Kacinski 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB

## Abstract We have previously reported that glucocorticoids markedly increase and anti‐glucocorticoids (such as RU‐486) block c‐__fms__ RNA and protein expression in some breast cancer cell lines, but not in others, and that this increase is the consequence of increased transcription from the firs