This review focuses on the possible role of transforming growth factor-~3 isoforms 1-3 (TGF~3) in prostate cancer. TGF~ 1 appears to inhibit the cellular proliferation of normal prostate cells. Surprisingly, TGF[31 is overexpressed in prostate cancer. To help explain this apparent paradox, it has be
Transforming growth factor-βs and their receptors in aging rat prostate
✍ Scribed by Hong Zhao; Aditi Patra; Yuichiro Tanaka; Long-Cheng Li; Rajvir Dahiya
- Book ID
- 117051962
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 332 KB
- Volume
- 294
- Category
- Article
- ISSN
- 0006-291X
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Transforming growth factor β 1 (TGF-β 1 ) has been implicated as inhibitor of cell proliferation and a potent inducer of apoptosis in vitro and in vivo after the administration of high doses. To assess the role of endogenous TGF-β 1 , we quantitated the cytokine and its receptors in rat liver during
Type /3 transforming growth factors are a group of homologous structurally related polypeptides that act on a wide variety of cell types to alter their proliferative and phenotypic properties. TGF-0s form a group within a larger family of polypeptides that control developmental processes in organism