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Multiple type-β transforming growth factors and their receptors

✍ Scribed by Joan Massagué; Sela Cheifetz; Ronald A. Ignotz; Frederick T. Boyd

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
501 KB
Volume
133
Category
Article
ISSN
0021-9541

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✦ Synopsis

Type /3 transforming growth factors are a group of homologous structurally related polypeptides that act on a wide variety of cell types to alter their proliferative and phenotypic properties. TGF-0s form a group within a larger family of polypeptides that control developmental processes in organisms from humans to Drosophila. We have found that at least three distinct forms of TGF-0 are present in mammalian tissues. We have identified a family of cell surface glycoproteins that bind TGF-0s with high affinity and specificity. Examination of the interactions between individual forms of TGF-0 and the individual TGF-0 receptor species has illustrated a complex pattern of ligandreceptor associations. Occupancy of a particular receptor type by TGF-/3 can be correlated to t h e dictation of specific effects on cell proliferation and cell differentiation.

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