𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Transforming growth factor-β and prostate cancer

✍ Scribed by M. S. Steiner

Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
991 KB
Volume
13
Category
Article
ISSN
0724-4983

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✦ Synopsis

This review focuses on the possible role of transforming growth factor-~3 isoforms 1-3 (TGF~3) in prostate cancer. TGF~ 1 appears to inhibit the cellular proliferation of normal prostate cells. Surprisingly, TGF[31 is overexpressed in prostate cancer. To help explain this apparent paradox, it has been revealed that with tumor progression, prostate cancer cells acquire reduced sensitivity to the growth-inhibitory effects of TGF~I. Aberrations of the TGF~31 signaling pathway at the prereceptor, receptor, or postreceptor level may lead to prostate cancer cell resistance to TGF~I growth inhibition. Indirectly, elevated levels of TGF~31 may induce host effects that may be beneficial to prostate tumor growth by suppressing the immune system, promoting angiogenesis and extracellular matrix formation, and enhancing metastatic potential. Consequently, TGF~ 1 appears to be important in prostate carcinogenesis and tumorigenicity. TGF~32 and TGF~33 are only briefly presented as very little is known about their role in prostate cancer.

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