## Background: We investigated the role of the transforming growth factor beta (tgf-beta) family in the neoplastic progression of the human prostate. ## Methods: Expression of tgf-beta mrna was measured by northern blot analysis of tissue extracts, and tgf-beta protein by immunohistochemical anal
✦ LIBER ✦
Differential expression of transforming growth factor-β1 and β3 as well asC-FOSmRNA in normal human prostate, benign prostatic hyperplasia and prostatic cancer
✍ Scribed by V. W. Merz; A. M. Arnold; U. E. Studer
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 517 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0724-4983
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Transforming growth factor-b (TGF-b1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investi