Transforming growth factor-β signaling in cancer
✍ Scribed by Jeremy N. Rich; Anita J. Borton; Xiao-Fan Wang
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 140 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1059-910X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
DPC4/SMAD4 is a candidate tumor suppressor gene with a strikingly high frequency of gene alterations in pancreatic cancer that suggests a discrete role for DPC4 in these tumors. DPC4 tumor-suppressive function has been implicated to mediate the transforming growth factor-b (TGFb)±suppressive pathway
Transforming growth factor-s (TGFs) play a prominent role in tumour growth and metastasis by enhancing angiogenesis and suppressing immune surveillance. Despite the increased interest in the effect of TGFs on tumour progression, little is known about the importance of TGF3 and its receptor CD105