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Transforming growth factor β inhibits the action of stem cell factor on mouse and human hematopoietic progenitors

✍ Scribed by Ian K. Mcniece; Ivan Bertoncello; Jonathan R. Keller; Francis W. Ruscetti; Cynthia A. Hartley; Krisztina M. Zsebo

Book ID
112212335
Publisher
AlphaMed Press
Year
1992
Tongue
English
Weight
758 KB
Volume
10
Category
Article
ISSN
1066-5099

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Transforming growth factor-beta1 (TGF-beta1) has been described as an efficient growth inhibitor that maintains the CD34(+) hematopoietic progenitor cells in quiescence. The concept of high proliferative potential-quiescent cells or HPP-Q cells has been introduced as a working model to study the eff