Modulation of hematopoietic stem/progenitor cell engraftment by transforming growth factor β
✍ Scribed by Anne Wiesmann; MiJung Kim; Ann Georgelas; A.Elena Searles; Donna D. Cooper; Wayne F. Green; Gerald J. Spangrude
- Book ID
- 114217445
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 323 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0301-472X
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Transforming growth factor-beta1 (TGF-beta1) has been described as an efficient growth inhibitor that maintains the CD34(+) hematopoietic progenitor cells in quiescence. The concept of high proliferative potential-quiescent cells or HPP-Q cells has been introduced as a working model to study the eff
## Abstract The vascular cell responses to the type 1, 2, and 3 isoforms of transforming growth factor‐β (TGF‐β1, TGF‐β2, TGF‐β3) were studied using bovine aortic endothelial (BAECs) and smooth muscle cells (BASMC3) as well as rat epididymal fat pad microvascular endothelia (RFCs). Three distinct b