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Transforming Growth Factor β, Pleiotropic Regulator of Hematopoietic Stem Cells: Potential Physiological and Clinical Relevance

✍ Scribed by Francis W. Ruscetti; Stephen H. Bartelmez

Publisher
Carden Jennings Publishing
Year
2001
Tongue
English
Weight
219 KB
Volume
74
Category
Article
ISSN
0925-5710

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We have recently demonstrated that transforming growth factor (TGF)-Pl and TGF-02 are potent inhibitors of the growth and differentiation of murine and human hematopoietic cells. The proliferation of primary unfractionated murine bone marrow by interleukin-3 (IL-3) and human bone marrow by IL-3 or g