Transformation of polycythemia vera to ph-positive chronic myelogenous leukemia
β Scribed by Amin U. Haq
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 331 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0361-8609
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We report an 8-year-old boy with Ph-positive chronic myelogenous leukemia (CML) who showed a testicular tumor as the first manifestation of blastic crisis. Pathological examination of the excised testis revealed marked infiltration of immature cells, whereas bone marrow remained in the chronic phase
A 23-year-old man developed Ph'-positive chronic myelogenous leukemia in 1966. After two short courses of busulfan not associated with severe myelosuppression, the frequency of Ph'-positive metaphases in his bone marrow was 40%. Over the next eight years, he remained hematologically stable without f