Translocation (3;21) in Philadelphia chromosome—positive chronic myelogenous leukemia prior to the onset of blast crisis
✍ Scribed by Thomas Coyle; Vesna Najfeld
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 318 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0361-8609
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## Background: Patients with chronic myelogenous leukemia (cml) occasionally experience persistent thrombocythemia despite having adequate white blood cell (wbc) counts. trimethylenethiophosphoramide (thiotepa) is an alkylating agent that significantly inhibits platelet production. ## Methods: Th
A 23-year-old man developed Ph'-positive chronic myelogenous leukemia in 1966. After two short courses of busulfan not associated with severe myelosuppression, the frequency of Ph'-positive metaphases in his bone marrow was 40%. Over the next eight years, he remained hematologically stable without f