Transformation of refractory anemia with excess of blasts into acute myelogenous leukemia with Ph-negative chronic myelogenous leukemia-like characteristics

Chronic myelogenous leukemia: Prolonged

Chronic myelogenous leukemia: Prolonged survival with spontaneous decline in the frequency of Ph1-positive cells and subsequent development of mixed Ph1-positive and Ph1-negative blast crisis

✍ Frederick R. Appelbaum; Vesna Najfeld; Jack W. Singer 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 486 KB 👁 2 views

A 23-year-old man developed Ph'-positive chronic myelogenous leukemia in 1966. After two short courses of busulfan not associated with severe myelosuppression, the frequency of Ph'-positive metaphases in his bone marrow was 40%. Over the next eight years, he remained hematologically stable without f