Transfer of a factor stimulating amyloid production from man to mice
β Scribed by V. S. Rukosuev
- Publisher
- Springer US
- Year
- 1971
- Tongue
- English
- Weight
- 173 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0007-4888
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π SIMILAR VOLUMES
## Abstract Leukemic cells in the myeloblastic stage from a murine myeloid leukemia cell line (M1) were induced to differentiate to macrophages by lipopolysaccharide (LPS) from Gramβnegative bacteria. A granulocyteβmacrophage colonyβstimulating factor (CSF) was produced only during differentiation.
HeN mice were incubated for 3 days with the culture supernatant of an L-929 cell line containing macrophagecolony-stimulating factor. Approximately, 70% of the cells became phagocytic, adherent to plastic dishes and positive for nonspecific esterase staining. The adherent cells exhibited a weak tumo