✦ LIBER ✦

Production of a colony-stimulating factor following differentiation of leukemic myeloblasts to macrophages

✍ Scribed by Michiyuki Maeda; Yasuo Ichikawa

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 825 KB
Volume: 102
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041020307

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Leukemic cells in the myeloblastic stage from a murine myeloid leukemia cell line (M1) were induced to differentiate to macrophages by lipopolysaccharide (LPS) from Gram‐negative bacteria. A granulocyte‐macrophage colony‐stimulating factor (CSF) was produced only during differentiation. After induction of differentiation, the continued presence of LPS was necessary to stimulate the macrophages to release CSF.

In contrast, a macrophage cell line (Mm‐1) derived from the M1 line produced CSF without LPS‐stimulation, but CSF release was stimulated by the presence of LPS.

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